{"id":2968,"date":"2016-09-13T20:30:13","date_gmt":"2016-09-13T20:30:13","guid":{"rendered":"http:\/\/www.medicalmarijuanainc.com\/?p=17419"},"modified":"2016-09-13T20:30:13","modified_gmt":"2016-09-13T20:30:13","slug":"dr-titus-insights-cannabinoids-acid-form-showing-therapeutic-potential","status":"publish","type":"post","link":"https:\/\/medicalmarijuanainc.com\/2016\/09\/13\/dr-titus-insights-cannabinoids-acid-form-showing-therapeutic-potential\/","title":{"rendered":"Dr. Titus Insights: Cannabinoids in Acid Form Showing Therapeutic Potential"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">In the raw extract from the cannabis plant, be it the marijuana form, or the hemp CBD form \u2013 we find cannabinoids in their acid form, including THC-A (marijuana) and CBD-A (hemp). \u00a0Many clever and talented marijuana growers are now also growing a CBD-variety and many 50% \/ 50% strains are coming forth. \u00a0Some types of marijuana have now been grown with MORE CBD than THC. \u00a0These acids, when heated (or decarboxylated) will turn to the more \u201cactive\u201d form. \u00a0Thus THC-A when heated will turn to THC and similarly for CBD-A when heated will turn to CBD. \u00a0Both show therapeutic potential \u2013thus the subject of this week\u2019s newsletter.<\/span><\/p>\n<h3><strong>CBD-A, aka Cannabidiolic Acid, Has Shown to Inhibit Aggressive Breast Cancer Migration<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">A <\/span><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22963825\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">New Study Shows<\/span><\/a><span style=\"font-weight: 400;\"> that CBD-A (aka Cannabidiolic Acid, a major cannabinoid in hemp-for-fiber-type cannabis) is an Inhibitor of MDA-MR-231 Breast Cancer Cell Migration.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Further this is another novel mechanism of action that CBD-A generates as opposed to findings by Dr. Sean McAllister of California Pacific Medical Center \u2013 where his <\/span><a href=\"http:\/\/mct.aacrjournals.org\/content\/6\/11\/2921\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">now famous study<\/span><\/a><span style=\"font-weight: 400;\"> showed CBD (in active, not acid form) to be a Novel Inhibitor of Id-1 Gene Expression in Aggressive Breast Cancer Cells.<\/span><\/p>\n<p>The mechanism of action described in the study, headed by Dr. S. Takeda (with the Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Hiroshima International University and Dept. of Molecular Biology, Daiichi University of Pharmacy, Fukuoka, Japan), shows:<\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Cannabidiolic Acid to induce cannabinoid-mediated necrosis<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">CBD-A to be an inhibitor of MDA-MR-231 a widely used cancer cell line that is used in cancer biology<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">This action occurs because of the down regulation of COX-2 (cyclooxygenase, an enzyme). \u00a0In human invasive breast cancers, the excessive COX-2 expression has been detected in about 40% of all patients<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">The downregulation of COX-2 is possibly caused by the down-regulation of c-fos, a component of the activator protein-1 (AP-1) dimer complex. \u00a0This AP-1 dimer complex is a transcription factor for the positive regulation of the COX-2 gene.<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Thus CBD-A may be working with the body\u2019s DNA to alter the COX-2 gene transcription factor \u2013 and thus correcting the aggressive breast cancer proliferation<\/span><\/li>\n<\/ul>\n<p>Highlights of the study include:<\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Cannabidiolic Acid (CBD-A) exists as a MAJOR COMPONENT in fiber-type cannabis (hemp for industrial use, mainly textiles in this variety)<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">CBD-A is identified as an ACTIVE COMPONENT<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">CBD-A is an INHIBITOR of highly aggressive human breast cancer cell migration (aggressive cell migration = metastasis)<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">The mechanism of action responsible for the effects of CBD-A involves activation of RhoA<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">RhoA is an inhibitor of cancer cell activity<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">CBD has been shown to be a novel inhibitor of Id-1 gene expression in aggressive Breast Cancer Cells via Id-1 Gene Expression \u2013 <\/span><a href=\"http:\/\/mct.aacrjournals.org\/content\/6\/11\/2921\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">this research<\/span><\/a><span style=\"font-weight: 400;\"> by a team led by Dr. Sean McAllister of California Pacific Medical Center shows that malfunctioning Id-1 gene expression causes the metastatic effect of certain cancer cells, particularly breast cancer. \u00a0It seems that CBD has the ability to \u201cswitch off\u201d this malfunctioning Id-1 gene and thus causes programmed cell death (cellular apoptosis) of these cancerous cells. \u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">CBD <\/span><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16754784\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">has been shown<\/span><\/a><span style=\"font-weight: 400;\"> to similarly cause cellular apoptosis in leukemia cancer cells and research by a Dr. Robert J. McKallip from University of South Carolina shows that this is caused by activating certain enzymatic pathways. \u00a0Technically these enzymes known as \u00a0p22phox and NOX-4 control the expression or the ability of the body to produce them on-demand \u2013 and this has a hydrogen peroxide-like effect to cleanse tissues and allow the immune system to recognize these leukemia cells as harmful invaders \u2013 thus this begins the process of programmed cell death (cell apoptosis). \u00a0<\/span><\/p>\n<p>CBD-A now inhibits MDA-MR-231 cancer cells, the widely used cancer cell line being utilized by researchers.<\/p>\n<p>Cancer, we believe is a disease of metabolic error \u2013 and can be corrected by Nutrition (against Disease). \u00a0More below:<\/p>\n<p>Improvements in mitochondrial functioning \u2013 and if one believes the research of Dr. Otto Warburg, two-time Nobel Prize Winning Laureate, the cancer cell metabolism is different than normal healthy cell metabolism. \u00a0Healthy cells burn glucose for energy via a highly efficient and effective oxidative process. \u00a0Cancer cells revert to a less efficient fermentation process that leads to fungus, a change in the overall \u201cbiological terrain\u201d and here, bacteria and micro-organisms have to change shape and form (morph \/ pleomorphism) in order to survive. This can lead toward sickness, disease and even cancer \u2013 according to Biological Medicine proponents (mostly found in Europe).<\/p>\n<h3><strong>LEAF \u2013 A Short Documentary from Dr. William Courtney re THC-A<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">We also need to discuss that THC-A \u2013 another cannabis-family acid, this of marijuana-based cannabis \u2013 has also shown potential therapeutic application. \u00a0The short documentary, titled <\/span><a href=\"https:\/\/www.youtube.com\/watch?v=qa0nLdVJiIg\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Leaf<\/span><\/a><span style=\"font-weight: 400;\"> \u2013 provides anecdotal evidence of an individual\u2019s path toward improved health via juicing the raw leaves of the cannabis (marijuana) plant. \u00a0Here, presumably the young woman was receiving significant amounts of THC-A \u2013 and will hopefully lead researchers toward similar to CBD-A studies.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The raw juice of the cannabis plant <\/span><a href=\"https:\/\/www.youtube.com\/watch?v=qa0nLdVJiIg\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">has shown<\/span><\/a><span style=\"font-weight: 400;\"> potential therapeutic value for the high concentration of non-psychoactive THC-A. \u00a0This acid can be converted into THC active form via decarboxylation (gentle heating) process \u2013 and is why people smoke marijuana: to convert the acids into actives and thus get the psychoactive effect. \u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The story that inspired the Leaf documentary concerned a chronically ill young adult who had many disorders, including fibromyalgia, digestive and female-related disorders. \u00a0Having basically \u201cfailed\u201d the traditional Western medicine approach, she turned toward alternative and integrative possibilities. \u00a0Once she started juicing raw cannabis leaves, she saw a remarkable improvement in her overall health. \u00a0The juice of the raw cannabis (marijuana type) leaves of the plant seems to be rich in THC-A.<\/span><\/p>\n<p>THC-A by itself is actually non-psychoactive and only turns psychoactive when heated (decarboxylated). \u00a0Nonetheless, it seems that THC-A, like THC, has a more direct effect upon the CB1 receptor site than does CBD. \u00a0So to describe this phenomena, we may see THC and THC-A acting like an old fashioned \u201clock-and-key\u201d type of receptor site action. \u00a0CBD has a more peripheral effect on the CB-1 receptor \u2013 so more akin to an electronic door lock system \u2013 where one can open all four doors of a car plus the trunk with a frequency-based or \u201cvibration-based\u201d interaction. \u00a0So even though more indirect, the effect of CBD upon the CB-1 receptor can be dramatic.<\/p>\n<p><span style=\"font-weight: 400;\">This is why some patients and some conditions seem to respond to the acid forms of both THC and CBD. \u00a0Whether CBD-A has this lock-and-key effect upon CB-1 remains open for debate \u2013 nonetheless the cannabinoids in acid form do seem to hold therapeutic potential. \u00a0We look forward to keeping our readers more informed over the coming weeks and months as research comes forth.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">To good health,<\/span><\/p>\n<p>Stu<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">Stuart W Titus, PhD<\/span><\/p>\n<p><span style=\"font-weight: 400;\">President &amp; CEO<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Medical Marijuana Inc. (OTC: MJNA)<\/span>    \t<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the raw extract from the cannabis plant, be it the marijuana form, or the hemp CBD form \u2013 we find cannabinoids in their acid form, including THC-A (marijuana) and CBD-A (hemp). \u00a0Many clever and talented marijuana growers are now also growing a CBD-variety and many 50% \/ 50% strains are coming forth. \u00a0Some types [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2703,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[3,195,9],"tags":[],"class_list":["post-2968","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-company-news","category-dr-titus-insights","category-scientific-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Dr. Titus Insights: Cannabinoids in Acid Form Showing Therapeutic Potential - 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