{"id":2968,"date":"2016-09-13T20:30:13","date_gmt":"2016-09-13T20:30:13","guid":{"rendered":"http:\/\/www.medicalmarijuanainc.com\/?p=17419"},"modified":"2016-09-13T20:30:13","modified_gmt":"2016-09-13T20:30:13","slug":"dr-titus-insights-cannabinoids-acid-form-showing-therapeutic-potential","status":"publish","type":"post","link":"https:\/\/medicalmarijuanainc.com\/2016\/09\/13\/dr-titus-insights-cannabinoids-acid-form-showing-therapeutic-potential\/","title":{"rendered":"Dr. Titus Insights: Cannabinoids in Acid Form Showing Therapeutic Potential"},"content":{"rendered":"

In the raw extract from the cannabis plant, be it the marijuana form, or the hemp CBD form \u2013 we find cannabinoids in their acid form, including THC-A (marijuana) and CBD-A (hemp). \u00a0Many clever and talented marijuana growers are now also growing a CBD-variety and many 50% \/ 50% strains are coming forth. \u00a0Some types of marijuana have now been grown with MORE CBD than THC. \u00a0These acids, when heated (or decarboxylated) will turn to the more \u201cactive\u201d form. \u00a0Thus THC-A when heated will turn to THC and similarly for CBD-A when heated will turn to CBD. \u00a0Both show therapeutic potential \u2013thus the subject of this week\u2019s newsletter.<\/span><\/p>\n

CBD-A, aka Cannabidiolic Acid, Has Shown to Inhibit Aggressive Breast Cancer Migration<\/strong><\/h3>\n

A <\/span>New Study Shows<\/span><\/a> that CBD-A (aka Cannabidiolic Acid, a major cannabinoid in hemp-for-fiber-type cannabis) is an Inhibitor of MDA-MR-231 Breast Cancer Cell Migration.<\/span><\/p>\n

Further this is another novel mechanism of action that CBD-A generates as opposed to findings by Dr. Sean McAllister of California Pacific Medical Center \u2013 where his <\/span>now famous study<\/span><\/a> showed CBD (in active, not acid form) to be a Novel Inhibitor of Id-1 Gene Expression in Aggressive Breast Cancer Cells.<\/span><\/p>\n

The mechanism of action described in the study, headed by Dr. S. Takeda (with the Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Hiroshima International University and Dept. of Molecular Biology, Daiichi University of Pharmacy, Fukuoka, Japan), shows:<\/p>\n