{"id":2968,"date":"2016-09-13T20:30:13","date_gmt":"2016-09-13T20:30:13","guid":{"rendered":"http:\/\/www.medicalmarijuanainc.com\/?p=17419"},"modified":"2016-09-13T20:30:13","modified_gmt":"2016-09-13T20:30:13","slug":"dr-titus-insights-cannabinoids-acid-form-showing-therapeutic-potential","status":"publish","type":"post","link":"https:\/\/medicalmarijuanainc.com\/2016\/09\/13\/dr-titus-insights-cannabinoids-acid-form-showing-therapeutic-potential\/","title":{"rendered":"Dr. Titus Insights: Cannabinoids in Acid Form Showing Therapeutic Potential"},"content":{"rendered":"
In the raw extract from the cannabis plant, be it the marijuana form, or the hemp CBD form \u2013 we find cannabinoids in their acid form, including THC-A (marijuana) and CBD-A (hemp). \u00a0Many clever and talented marijuana growers are now also growing a CBD-variety and many 50% \/ 50% strains are coming forth. \u00a0Some types of marijuana have now been grown with MORE CBD than THC. \u00a0These acids, when heated (or decarboxylated) will turn to the more \u201cactive\u201d form. \u00a0Thus THC-A when heated will turn to THC and similarly for CBD-A when heated will turn to CBD. \u00a0Both show therapeutic potential \u2013thus the subject of this week\u2019s newsletter.<\/span><\/p>\n A <\/span>New Study Shows<\/span><\/a> that CBD-A (aka Cannabidiolic Acid, a major cannabinoid in hemp-for-fiber-type cannabis) is an Inhibitor of MDA-MR-231 Breast Cancer Cell Migration.<\/span><\/p>\n Further this is another novel mechanism of action that CBD-A generates as opposed to findings by Dr. Sean McAllister of California Pacific Medical Center \u2013 where his <\/span>now famous study<\/span><\/a> showed CBD (in active, not acid form) to be a Novel Inhibitor of Id-1 Gene Expression in Aggressive Breast Cancer Cells.<\/span><\/p>\n The mechanism of action described in the study, headed by Dr. S. Takeda (with the Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Hiroshima International University and Dept. of Molecular Biology, Daiichi University of Pharmacy, Fukuoka, Japan), shows:<\/p>\n Highlights of the study include:<\/p>\n CBD has been shown to be a novel inhibitor of Id-1 gene expression in aggressive Breast Cancer Cells via Id-1 Gene Expression \u2013 <\/span>this research<\/span><\/a> by a team led by Dr. Sean McAllister of California Pacific Medical Center shows that malfunctioning Id-1 gene expression causes the metastatic effect of certain cancer cells, particularly breast cancer. \u00a0It seems that CBD has the ability to \u201cswitch off\u201d this malfunctioning Id-1 gene and thus causes programmed cell death (cellular apoptosis) of these cancerous cells. \u00a0<\/span><\/p>\n CBD <\/span>has been shown<\/span><\/a> to similarly cause cellular apoptosis in leukemia cancer cells and research by a Dr. Robert J. McKallip from University of South Carolina shows that this is caused by activating certain enzymatic pathways. \u00a0Technically these enzymes known as \u00a0p22phox and NOX-4 control the expression or the ability of the body to produce them on-demand \u2013 and this has a hydrogen peroxide-like effect to cleanse tissues and allow the immune system to recognize these leukemia cells as harmful invaders \u2013 thus this begins the process of programmed cell death (cell apoptosis). \u00a0<\/span><\/p>\n CBD-A now inhibits MDA-MR-231 cancer cells, the widely used cancer cell line being utilized by researchers.<\/p>\n Cancer, we believe is a disease of metabolic error \u2013 and can be corrected by Nutrition (against Disease). \u00a0More below:<\/p>\n Improvements in mitochondrial functioning \u2013 and if one believes the research of Dr. Otto Warburg, two-time Nobel Prize Winning Laureate, the cancer cell metabolism is different than normal healthy cell metabolism. \u00a0Healthy cells burn glucose for energy via a highly efficient and effective oxidative process. \u00a0Cancer cells revert to a less efficient fermentation process that leads to fungus, a change in the overall \u201cbiological terrain\u201d and here, bacteria and micro-organisms have to change shape and form (morph \/ pleomorphism) in order to survive. This can lead toward sickness, disease and even cancer \u2013 according to Biological Medicine proponents (mostly found in Europe).<\/p>\n We also need to discuss that THC-A \u2013 another cannabis-family acid, this of marijuana-based cannabis \u2013 has also shown potential therapeutic application. \u00a0The short documentary, titled <\/span>Leaf<\/span><\/a> \u2013 provides anecdotal evidence of an individual\u2019s path toward improved health via juicing the raw leaves of the cannabis (marijuana) plant. \u00a0Here, presumably the young woman was receiving significant amounts of THC-A \u2013 and will hopefully lead researchers toward similar to CBD-A studies.<\/span><\/p>\nCBD-A, aka Cannabidiolic Acid, Has Shown to Inhibit Aggressive Breast Cancer Migration<\/strong><\/h3>\n
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LEAF \u2013 A Short Documentary from Dr. William Courtney re THC-A<\/strong><\/h3>\n