{"id":2944,"date":"2016-10-21T19:33:07","date_gmt":"2016-10-21T19:33:07","guid":{"rendered":"http:\/\/www.medicalmarijuanainc.com\/?p=18080"},"modified":"2016-10-21T19:33:07","modified_gmt":"2016-10-21T19:33:07","slug":"dr-titus-insights-nsaids-flavonoids-autism","status":"publish","type":"post","link":"https:\/\/medicalmarijuanainc.com\/2016\/10\/21\/dr-titus-insights-nsaids-flavonoids-autism\/","title":{"rendered":"Dr. Titus Insights: NSAIDs, Flavonoids, and Autism"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">This week: <\/span><\/p>\n<ul>\n<li><span style=\"font-weight: 400;\">Many Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) are now Associated with Heart Failure<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Cannabis Flavonoids \u2013 Emerging Therapeutic Applications<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Marijuana Arrests Fall to a 20 Year Low<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Autism Patents Now Treating Children with Cannabis<\/span><\/li>\n<\/ul>\n<p><strong>Many Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) are now Associated with Heart Failure<\/strong><\/p>\n<p><span style=\"font-weight: 400;\">Many commonly used non-steroidal anti-inflammatory drugs (NSAIDs) are now associated with elevated risk of heart failure hospitalizations, a <\/span><a href=\"http:\/\/www.medpagetoday.com\/Cardiology\/CHF\/60513?xid=nl_mpt_DHE_2016-09-30&amp;eun=g998806d0r&amp;pos=0\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">case-controlled European study has shown<\/span><\/a><span style=\"font-weight: 400;\">. \u00a0The effects appeared to be dose-related, such that the risk of heart-failure doubled when certain NSAIDs were used at twice the recommended daily allowable dosage. \u00a0The researchers further noted that \u201ceven medium doses\u201d\u2026 (at recommended daily allowable levels) of certain NSAIDs \u201cwere associated with increased risk\u201d. \u00a0<\/span><\/p>\n<p>The study was performed by Dr. Giovanni Corrao, PhD of Italy\u2019s University of Milano-Bicocca and was reported in the British Medical Journal. \u00a0Dr. Corrao\u2019s study included over 92,000 hospital admissions for heart failure and 8.2 million adults who started NSAIDs therapy from 2000 to 2010 in the Netherlands, Italy, Germany and the UK.<\/p>\n<p>The overall link between heart failure and NSAIDs \u201chas been known for over 20 years and is likely related to the predilection of these drugs to cause retention of salt and water plus increases in blood pressure,\u201d commented Dr. Milton Packer, MD of Baylor University Medical Center in Dallas, Texas.<\/p>\n<p>While the FDA and other agencies have warned about potential risks of NSAIDs, their wide over-the-counter use \u201cfuels the common misconception that NSAIDs are harmless drugs that are safe for everyone\u201d and makes \u201ceven a small increase in cardiovascular risk\u2026 a concern for public health,\u201d the BMJ editorial said.<\/p>\n<p>\u201cTherefore a more restricted policy by regulatory authorities on the availability of NSAIDs and requirements for healthcare professionals providing advice on their use and potential harm is warranted.\u201d<\/p>\n<p>The time has come to evaluate marijuana\u2019s potential for improving the lives of these pain patients. \u00a0A natural botanical, with zero side effects, no one has ever overdosed and died as a result of an \u201coverdose\u201d of botanical cannabis. \u00a0Significant pain relief and central nervous system relaxation benefits have been shown anecdotally, and soon we hope to have more formal pain-related trials to compare vs. NSAIDs.<\/p>\n<p><span style=\"font-weight: 400;\">Article: <\/span><a href=\"http:\/\/www.medpagetoday.com\/Cardiology\/CHF\/60513?xid=nl_mpt_DHE_2016-09-30&amp;eun=g998806d0r&amp;pos=0\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">http:\/\/www.medpagetoday.com\/Cardiology\/CHF\/60513?xid=nl_mpt_DHE_2016-09-30&amp;eun=g998806d0r&amp;pos=0<\/span><\/a><\/p>\n<p><strong>Cannabis Flavonoids \u2013 Emerging Therapeutic Applications<\/strong><\/p>\n<p>Flavonoids are a group of phytonutrients most remarkably known for providing vivid non-green pigments to the plant kingdom, such as the blue in blueberries, the red in red roses and the purple in your Granddaddy Purp Cannabis. \u00a0Alongside cannabinoids (such as THC and CBD) and terpenoids (such as myrcene and limonene), flavonoids in cannabis also produce a range of effects. \u00a0Commonly grouped together, flavonoids combine together to support the other cannabis phytonutrients \u2013 and play a highly bioactive role in the plant\u2019s consumption and cultivation.<\/p>\n<p><span style=\"font-weight: 400;\">When cannabis is consumed, flavonoids contribute to the color, taste, smell, entourage effect and overall sensory experience. \u00a0While contributing to health benefits of the cannabis plant, these flavonoids also have a great reputation among the wellness community for providing a range of health benefits to humans.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Federal prohibition has prevented more study and research in regards to cannabis related flavonoids; however, this class represents one of the largest nutrient families known to science. \u00a0Over 6,000 individual flavonoids have been identified and many are found in the fruits, vegetables and herbs that we routinely consume. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">A type of flavonoid found in green tea and cacao known as \u201ccatechins\u201d is known to provide antioxidant and cardiovascular health benefits, while also providing favorable effects upon cholesterol levels in humans. \u00a0Another flavonoid, known as \u201cquercetin\u201d which is readily available in many fruits and vegetables (as well as in cannabis) is known for having potential antioxidant and anti-viral properties. \u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Certain flavonoids are unique to the cannabis plant and are now referred to as \u201ccannaflavins\u201d and research is underway to distinguish cannaflavins from more common flavonoids. \u00a0Recently it was discovered that a cannaflavin known as \u201cCannaflavin-A\u201d inhibits PGE-2, a prostaglandin responsible for inflammation \u2013 similar to the effect of NSAIDs like aspirin. \u00a0The <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3754224\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">research study <\/span><\/a><span style=\"font-weight: 400;\">showed that \u201cCannaflavin-A\u201d reduces inflammation and is exponentially more powerful than aspirin.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cannaflavin-B and Cannaflavin-C are being studied as well. \u00a0Researchers continue their work on more common flavonoids in plants that also appear in cannabis: such as beta-sitosterol, vitexin, isovitexin, apigenin, kaempferol, quercetin, luteolin and orientin \u2013 whether these flavonoids enhance or reduce certain effects of cannabis based cannabinoids and\/or terpenoids. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">Because of the high level of anti-inflammatory properties that support detoxification of tissue-damaging molecules, flavonoids consumption if often associated with reduced risk of certain cancers, most notably lung and breast cancer. \u00a0Flavonoids are readily found on the cured leaves and flowers of cannabis and through advanced extraction techniques, we may soon be combining cannabinoids with a ribbon of \u201cflav\u201d oil. \u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here is a list of some major flavonoids, potential therapeutic effects and their corresponding vaporization temperatures:<\/span><\/p>\n<ul>\n<li><span style=\"font-weight: 400;\">Beta-sitosterol: 273 degrees F; anti-inflammatory<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Apigenin; 352 degrees F; estrogenic, anxiolytic, anti-inflammatory<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Cannaflavin-A; 360 degrees F; anti-inflammatory<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Quercetin; 482 degrees F; antioxidant, antiviral<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">More info: <\/span><a href=\"https:\/\/www.merryjane.com\/health\/flavonoids-cannabis\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">https:\/\/www.merryjane.com\/health\/flavonoids-cannabis<\/span><\/a><\/p>\n<p><strong>Marijuana Arrests Fall to a 20 Year Low<\/strong><\/p>\n<p>Marijuana arrests fall to a 20-year-low, but someone is still getting busted about every minute. \u00a0Police made fewer arrests for marijuana-related offenses last year than they have for any year since 1986, according to FBI crime data recently released. \u00a0Still authorities made 643,000 arrests for marijuana-related charges in 2015 \u2013 or about one every 49 seconds. \u00a0Charges related to marijuana possession and sale accounted for about 43.2 percent of all drug arrests.<\/p>\n<p><span style=\"font-weight: 400;\">With support for marijuana legalization at an all-time high, Tom Angell, chairman of the drug policy reform group, Marijuana Majority, told the Huffington Post that \u201claw enforcement\u2019s priorities are still out of synch with the majority of Americans.\u201d \u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The Drug Policy Alliance group mentions that a \u201cmarijuana arrest is no small matter\u201d. \u00a0Most people so arrested are held in jail for a day or more, and many are permanently branded with a criminal record which can hurt their employment, educational access or housing. \u00a0Additionally, a one-year Huffington Post analysis of jail deaths found that several inmates arrested on a marijuana offense died behind bars. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">Such arrests are costly too. \u00a0Authorities spend about $3.6 billion annually enforcing laws against marijuana possession, according to the ACLU (American Civil Liberties Union). \u00a0\u201cWhile the numbers are thankfully dropping over time, it\u2019s alarming and simply unacceptable that someone is harassed by the police just for marijuana every 49 seconds in this country\u201d said Tom Angell. \u00a0\u201cPolls now consistently show that a growing majority of Americans support full legalization and it\u2019s about time more politicians and law enforcement caught up.\u201d <\/span><\/p>\n<p><span style=\"font-weight: 400;\">Article: <\/span><a href=\"http:\/\/www.huffingtonpost.com\/entry\/marijuana-drug-arrests-2015_us_57e9776de4b0e28b2b5585f7\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">http:\/\/www.huffingtonpost.com\/entry\/marijuana-drug-arrests-2015_us_57e9776de4b0e28b2b5585f7<\/span><\/a><\/p>\n<p><strong>Autism Patents Now Treating Children with Cannabis<\/strong><\/p>\n<p><span style=\"font-weight: 400;\">Autism parents are treating children with cannabis, and at the crux of the contradictions lie important questions: is marijuana a legitimate treatment for autism and is it safe to give to children\u2026? \u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Orrin Devinsky, a neurologist at New York University is studying the effect of CBD on epilepsy says, \u201cI am okay with approving these things and making them accessible for people with treatment-resistant problems.\u201d \u00a0\u201cBy the same token, we as a political, medical and scientific society should be moving for high quality scientific data. \u00a0If its safe and effective people should be able to use their prescription plans and get it (cannabis); if it\u2019s dangerous or ineffective, nobody should get access to it.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although cannabis is allowed for medicinal usage in 25 US States plus the District of Columbia, only Pennsylvania in their relatively recent legislation, allows for cannabis to be used for Autism. \u00a0In recent years, parents of children with both epilepsy and autism have adopted the cannabis approach. \u00a0Many mothers are true cannabis pioneers in search of solutions to assist their children.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A wonderful story about these pioneering parents is found here: <\/span><a href=\"https:\/\/spectrumnews.org\/features\/deep-dive\/the-pioneers-parents-treating-autism-with-marijuana\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">https:\/\/spectrumnews.org\/features\/deep-dive\/the-pioneers-parents-treating-autism-with-marijuana\/<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Isn\u2019t it about time that more research is allowed into these potentially beneficial emerging therapeutics that can assist families\u2026? \u00a0Certainly when a prominent physician with the stature and credibility of Dr. Orrin Devinsky calls for more research to be undertaken. \u00a0We certainly applaud Dr. Devinsky for his forward thinking regarding forms of cannabis that may assist families where there is little to no other hope.<\/span><\/p>\n<p>To good health,<\/p>\n<p>Stu<\/p>\n<p><span style=\"font-weight: 400;\">Stuart W Titus, PhD<\/span><\/p>\n<p><span style=\"font-weight: 400;\">President &amp; CEO<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Medical Marijuana Inc. (OTC: MJNA)<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This week: Many Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) are now Associated with Heart Failure Cannabis Flavonoids \u2013 Emerging Therapeutic Applications Marijuana Arrests Fall to a 20 Year Low Autism Patents Now Treating Children with Cannabis Many Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) are now Associated with Heart Failure Many commonly used non-steroidal anti-inflammatory drugs (NSAIDs) are now associated [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2738,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[3,195,9],"tags":[],"class_list":["post-2944","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-company-news","category-dr-titus-insights","category-scientific-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.1 - 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