{"id":2794,"date":"2017-03-30T09:39:20","date_gmt":"2017-03-30T09:39:20","guid":{"rendered":"http:\/\/www.medicalmarijuanainc.com\/?p=22723"},"modified":"2017-03-30T09:39:20","modified_gmt":"2017-03-30T09:39:20","slug":"axim-biotechnologies-develop-chewing-gum-bioequivalence-marinol","status":"publish","type":"post","link":"https:\/\/medicalmarijuanainc.com\/2017\/03\/30\/axim-biotechnologies-develop-chewing-gum-bioequivalence-marinol\/","title":{"rendered":"AXIM\u00ae Biotechnologies to Develop Chewing Gum with Bioequivalence to Marinol\u00ae"},"content":{"rendered":"<p>[vc_row][vc_column][vc_column_text]<\/p>\n<h3><em><span style=\"font-weight: 400\">AXIM\u00ae Biotechnologies, a major Medical Marijuana, Inc. investment company, has taken the first steps toward developing a chewing gum bioequivalent to Marinol, made using a synthetic version of THC or tetrahydrocannabinol.<\/span><\/em><\/h3>\n<p><span style=\"font-weight: 400\">This week, AXIM\u00ae Biotechnologies revealed that it entered into a Term Sheet Agreement with a U.S.-based Active Pharmaceutical Ingredient (API) production company. Through this agreement, AXIM\u00ae will create a functional dronabinol-based chewing gum similar to Marinol using the company\u2019s intellectual property, including their patent on CBD-based controlled release chewing gum that was recently expanded to include all cannabinoids, including THC. <\/span><\/p>\n<p><span style=\"font-weight: 400\">AXIM\u00ae will be creating their new drug using dronabinol, an isomer of THC that was originally used to make Marinol. First introduced in the U.S. market in 1985, Marinol remains the only FDA approved cannabis-based drug available in the U.S. Axim\u00ae\u2019s dronabinol-based gum is intended as a design improvement over Marinol, addressing both safety and efficiency. <\/span>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_single_image image=&#8221;22589&#8243; img_size=&#8221;full&#8221;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<span style=\"font-weight: 400\">&#8220;AXIM has once again expanded its clinical research program in an impressive and important way that will greatly benefit this population of patients,&#8221; said Dr. Stuart Titus, PhD, CEO of Medical Marijuana, Inc. &#8220;With more than a third of patients discontinuing use of Marinol as prescribed due to adverse side effects, it is encouraging that AXIM\u00ae will research and attempt to bring to market an improved medication that may provide expanded therapeutics while allowing for a better quality of life for this patient population.&#8221;<\/span><\/p>\n<p><span style=\"font-weight: 400\">Marinol may be prescribed for the treatment of <\/span><a href=\"https:\/\/medicalmarijuanainc.com\/cachexia-medical-marijuana-research\/\"><span style=\"font-weight: 400\">cachexia<\/span><\/a><span style=\"font-weight: 400\"> (weight loss) in patients with <\/span><a href=\"https:\/\/medicalmarijuanainc.com\/hiv-aids-medical-marijuana-research\/\"><span style=\"font-weight: 400\">AIDS<\/span><\/a><span style=\"font-weight: 400\"> and for the treatment of <\/span><a href=\"https:\/\/medicalmarijuanainc.com\/nausea-2-medical-marijuana-research\/\"><span style=\"font-weight: 400\">nausea<\/span><\/a><span style=\"font-weight: 400\"> and vomiting associated with <\/span><a href=\"https:\/\/medicalmarijuanainc.com\/chemotherapy-side-effects-medical-marijuana-research-overview\/\"><span style=\"font-weight: 400\">cancer treatment<\/span><\/a><span style=\"font-weight: 400\">. Marinol is typically reserved for patients who have failed to respond adequately to conventional antiemetic treatments. AXIM\u00ae will pursue these same indications in its clinical research on their chewing gum replacement. The total market size for Marinol and generic dronabinol products has reached <\/span><a href=\"https:\/\/www.fool.com\/investing\/2016\/07\/20\/this-marijuana-drugmaker-sets-its-sights-on-a-9-fi.aspx\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">$150 million<\/span><\/a><span style=\"font-weight: 400\"> for all indications. <\/span><\/p>\n<p><span style=\"font-weight: 400\">Marinol is manufactured as a gelatin capsule containing synthetic delta-9-tetrahydrocannabinol (THC) in sesame oil. It is taken orally and is available in 2.5mg, 5mg and\/or 10mg dosages. In its current capsule form, Marinol is metabolized into 11-OH- THC when it passes through the liver. This metabolite causes significant side effects for patients, including impaired thinking, lightheadedness, negative mood changes, and other adverse reactions. <\/span><\/p>\n<p><span style=\"font-weight: 400\">AXIM&#8217;s patented controlled release chewing gum largely bypasses the first pass metabolism in the liver to the point where AXIM\u00ae Biotechnologies believes their new formulation will improve efficacy while simultaneously reducing side effects for patients who utilize this new delivery method.<\/span><\/p>\n<p><span style=\"font-weight: 400\">This preliminary agreement between AXIM\u00ae Biotechnologies and its API company creates the necessary conditions for AXIM\u00ae to move forward with their pursuit of this improved delivery system for FDA approved dronabinol. <\/span><\/p>\n<p><span style=\"font-weight: 400\">Read more about AXIM\u00ae Biotechnologies and the rest of the Medical Marijuana, Inc. family of investment companies by <\/span><a href=\"https:\/\/medicalmarijuanainc.com\/news\/\"><span style=\"font-weight: 400\">following our news feed<\/span><\/a><span style=\"font-weight: 400\">. <\/span>[\/vc_column_text][\/vc_column][\/vc_row]    \t<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] AXIM\u00ae Biotechnologies, a major Medical Marijuana, Inc. investment company, has taken the first steps toward developing a chewing gum bioequivalent to Marinol, made using a synthetic version of THC or tetrahydrocannabinol. This week, AXIM\u00ae Biotechnologies revealed that it entered into a Term Sheet Agreement with a U.S.-based Active Pharmaceutical Ingredient (API) production company. Through [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2795,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[160,3,9],"tags":[183],"class_list":["post-2794","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-axim-biotechnologies","category-company-news","category-scientific-research","tag-axim-biotechnologies"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>AXIM\u00ae Biotechnologies to Develop Chewing Gum with Bioequivalence to Marinol\u00ae - Medical Marijuana, Inc.<\/title>\n<meta name=\"description\" content=\"AXIM\u00ae Biotechnologies entered a Term Sheet Agreement with an API production company to create a functional dronabinol-based chewing gum similar to Marinol.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicalmarijuanainc.com\/2017\/03\/30\/axim-biotechnologies-develop-chewing-gum-bioequivalence-marinol\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AXIM\u00ae Biotechnologies to Develop Chewing Gum with Bioequivalence to Marinol\u00ae - 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